Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using Plga-Peg-Fol Polymer

Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using PLGA-PEG-FOL Polymer

Purpose: This article describes the preparation and characterization of folate conjugated nanoparticles using poly(lactide-co-glycolide)-poly(ethylene glycol)-folate (PLGA-PEG-FOL) polymer for targeted delivery of anticancer agents. Methods: PLGA-PEG-FOL was synthesized by coupling di-block copolymer (PLGA-PEG-NH2) with folic acid. PLGA-PEG-FOL polymer was characterized by 1H NMR, GPC and FTIR....

Theoretical Study on Physicochemical and Geometrical Properties of Doxorubicin-PEG-FOL Nanoparticles and Daunorubicin-PEG-FOL Nanoparticles

The physicochemical properties of Doxorubicin–PEG–FOL and Daunorubicin-PEG-FOL ( Doxorubicin and Daunorubicin conjugated to polyethylene glycol–folate nanoparticles) have been estimated using Density functional Theory (DFT) and Hartree Fock(HF) calculations.In this report some geometrical parameters of Doxorubicin-PEG-FOL complex of the conjugated complex and Daunorubicin–PEG–FOL complex of the...

Highly emissive PEG-encapsulated conjugated polymer nanoparticles.

A novel bioimaging probe based on a conjugated polymer, poly(9,9-dihexylfluorene-alt-2,1,3-benzoxadiazole) (PFBD), is demonstrated. Transfer of the hydrophobic polymer into water using a short chain poly(ethylene glycol) (PEG) resulted in conjugated polymer nanoparticles (PEG-PFBD) with a fluorescence quantum yield of 46%. The PEG-PFBD nanoparticles possessed several desirable structural and ph...

Preparation, characterization and evaluation of docetaxel-loaded, folate-conjugated PEG-liposomes.

For the purpose of enhancing the anticancer potency of docetaxel, a novel excipient, cholesterol-PEG-folate (α-(3.beta) cholest-5-en-3-ω-folic acid-poly (oxy-1, 2-ethanediyl)), was synthesized and used for the preparation of liposomes (folate-conjugated PEG-liposomes). The in vitro release properties, in vitro cytotoxicity, in vivo pharmacokinetics and distribution, as well as in vivo potency o...

synthesis of peg-plga copolymer for preparation of docetaxel nanoparticles